1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid
CAS: 215190-19-5
Molecular Formula: C27H25NO4
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid - Names and Identifiers
| Name | 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid |
| Synonyms | RARECHEM EM WB 0183 FMOC-4-PHENYL-ISONIPECOTIC ACID FMOC-4-PHENYL-4-PIPERIDINECARBOXYLIC ACID FMOC-4-PHENYL-PIPIRIDINE-4-CARBOXYLIC ACID FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid 1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-phenylpiperidine-4-carboxylic acid |
| CAS | 215190-19-5 |
| InChI | InChI=1/C27H25NO4/c29-25(30)27(19-8-2-1-3-9-19)14-16-28(17-15-27)26(31)32-18-24-22-12-6-4-10-20(22)21-11-5-7-13-23(21)24/h1-13,24H,14-18H2,(H,29,30) |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C27H25NO4 |
| Molar Mass | 427.49 |
| Density | 1.278g/cm3 |
| Boling Point | 633.8°C at 760 mmHg |
| Flash Point | 337.1°C |
| Vapor Presure | 6.2E-17mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.635 |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid - Risk and Safety
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid - Introduction
1-[(9H-fluoren-9-ylmethoxy)]-carbonic acid, also known as 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-phenylpiperidine-4-carboxylic acid, it is an organic compound. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: White or slightly yellow crystalline powder
-molecular formula: C28H23NO4
-Molecular weight: 441.49g/mol
-Melting point: 183-188 ° C
-Solubility: Soluble in organic solvents such as methylene chloride, dimethyl sulfite and methanol
Use:
- 1-[(9H-fluoren-9-ylmethoxy)-benzol is a commonly used reagent to construct acid, which is commonly used in solid-phase synthesis of piperidine skeleton.
-It can be used for the synthesis of peptides, proteins and other small organic compounds.
-In solid phase synthesis, it can be used as a protecting group (Fmoc protecting group) to generate active amino acids or peptide fragments through reaction.
Method:
The preparation of 1-[(9H-fluoren-9-ylmethoxy)]-carbonyl can be carried out by the following steps:
1. Dissolve 4-phenylpiperidine in dimethylsulfite.
2. Suspend fluorenecyl chloride in the above solution at low temperature.
3. Slowly add sodium bicarbonate solution under alkaline conditions.
4. After formation of precipitate, filter and wash.
5. The target product 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-fluoryl acid can be obtained after the obtained product is properly Crystal treated.
Safety Information:
- 1-[(9H-fluoren-9-ylmethoxy)]-carbonyl is generally stable and harmless under normal use and storage conditions.
-However, as a chemical, it is still necessary to pay attention to safe operation when handling and using.
-Contact with strong oxidants and high temperature conditions must be avoided.
-Appropriate protective measures, such as laboratory gloves and goggles, should be worn.
-When storing, keep dry, avoid sun exposure, and keep away from flammable and explosive materials.
Nature:
-Appearance: White or slightly yellow crystalline powder
-molecular formula: C28H23NO4
-Molecular weight: 441.49g/mol
-Melting point: 183-188 ° C
-Solubility: Soluble in organic solvents such as methylene chloride, dimethyl sulfite and methanol
Use:
- 1-[(9H-fluoren-9-ylmethoxy)-benzol is a commonly used reagent to construct acid, which is commonly used in solid-phase synthesis of piperidine skeleton.
-It can be used for the synthesis of peptides, proteins and other small organic compounds.
-In solid phase synthesis, it can be used as a protecting group (Fmoc protecting group) to generate active amino acids or peptide fragments through reaction.
Method:
The preparation of 1-[(9H-fluoren-9-ylmethoxy)]-carbonyl can be carried out by the following steps:
1. Dissolve 4-phenylpiperidine in dimethylsulfite.
2. Suspend fluorenecyl chloride in the above solution at low temperature.
3. Slowly add sodium bicarbonate solution under alkaline conditions.
4. After formation of precipitate, filter and wash.
5. The target product 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-fluoryl acid can be obtained after the obtained product is properly Crystal treated.
Safety Information:
- 1-[(9H-fluoren-9-ylmethoxy)]-carbonyl is generally stable and harmless under normal use and storage conditions.
-However, as a chemical, it is still necessary to pay attention to safe operation when handling and using.
-Contact with strong oxidants and high temperature conditions must be avoided.
-Appropriate protective measures, such as laboratory gloves and goggles, should be worn.
-When storing, keep dry, avoid sun exposure, and keep away from flammable and explosive materials.
Last Update：2024-04-10 22:29:15
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Product Name: FMOC-4-PHENYL-PIPERIDINE-4-CARBOXYLIC ACID Visit Supplier Webpage Request for quotation
CAS: 215190-19-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 215190-19-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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